Drug Detail

Information about THE-630

Generic Name
IND	THE-630
Brand Name (US)
Manufacturer	Theseus
Drug Type
Delivery	Oral
Approval Status
Indications
Overall Strategy	KIT Protein Based
Strategy	Block KIT
Drug Category	KIT Inhibitor

PDGFRA V561D (IC50 <5 nM)

THE-630 not designed to potently inhibit PDGFR D842V (GIST) and KIT D816V (mastocytosis) activating mutations
− IC50 >100 nM in BaF3 cellular assays.