Drug Detail

Information about Velzatinib

Generic Name
 Velzatinib
IND
 GSK6042981
Brand Name (US)
Manufacturer
 GlaxoSmithKline
Drug Type
 Tyrosine Kinase Inhibitor
Delivery
 Oral
Approval Status
 Phase 3
Indications
 GIST
Overall Strategy
 Inhibit KIT/PDGFRa
Strategy
 Block KIT/PDGFRA
Drug Category
 KIT/PDGFRA inhibitor

Links

 

 The Potential of c-KIT Kinase inhibitors in Cancer Treatment
   

 

 MedCity News 8/2/2022: Aiming to bring drug combos into earlier lines of cancer therapy, IDRx lands $122M
   

 

 IDRx Presents Preliminary Clinical Data from Ongoing Phase 1 StrateGIST Study at CTOS 2023 Supporting Best-in-Class Potential of IDRX-42 in Patients with GIST
   

 

 Merck 2/28/2025 M4205 (IDRX-42) is a highly selective and potent inhibitor of relevant oncogenic driver and resistance variants of KIT in cancer
   

Trials of this drug

  

 First-in-human Study of IDRX-42 in Participants With Metastatic and/​or Unresectable Gastrointestinal Stromal Tumors
   

  

 A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy (StrateGIST 3)
   

  

 Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/​or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline)
   

Trial results
  IDRx Presents Preliminary Clinical Data from Ongoing Phase 1 StrateGIST Study at CTOS 2023 Supporting Best-in-Class Potential of IDRX-42 in Patients with GIST
   
  CTOS 2023 Schoffski poster
   

Search for this drug/combination in:

ClinicalTrials.gov

ASCO

Pubmed